Autistic individuals have impaired communication and social behaviour. Genes operating across a wide range of different biological functions have been identified as being associated with an increased risk of autism. However, it is currently unclear how variation in a number of these genes brings about changes in signalling to disrupt the output of neural circuits. They have developed a pipeline using the model organism C. elegans to identify genes that function to co-ordinate social behaviour. Of these, a subset function within epigenetic and lipid signalling pathways and represent interesting targets for the development of therapeutic approaches.
*Due to funding restrictions this position is only open to UK/EU applicants
University of Southampton
United Kingdom › Southampton
31st March 2022