{"id":49786,"date":"2020-07-24T03:00:10","date_gmt":"2020-07-24T01:00:10","guid":{"rendered":"https:\/\/www.cde.ual.es\/?p=49786"},"modified":"2020-07-23T11:38:18","modified_gmt":"2020-07-23T09:38:18","slug":"how-covid-19-damages-the-lungs","status":"publish","type":"post","link":"https:\/\/www.cde.ual.es\/en\/how-covid-19-damages-the-lungs\/","title":{"rendered":"How COVID-19 damages the lungs"},"content":{"rendered":"<p class=\"c-teaser\"><strong>A team of EU-backed researchers has compared the lungs of coronavirus victims and patients dead from influenza-associated respiratory failure.<\/strong><\/p>\n<p><a href=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2020\/07\/lung.jpg\"><img decoding=\"async\" class=\"wp-image-49783 aligncenter\" src=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2020\/07\/lung-300x200.jpg\" alt=\"\" width=\"401\" height=\"267\" srcset=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2020\/07\/lung-300x200.jpg 300w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2020\/07\/lung-1024x682.jpg 1024w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2020\/07\/lung-768x511.jpg 768w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2020\/07\/lung.jpg 1280w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><\/a><\/p>\n<div class=\"container-fluid\">\n<div class=\"row c-article__below-teaser\">\n<div>Why does the coronavirus impact the lungs so brutally?<\/div>\n<\/div>\n<div>Partially supported by the EU-funded <strong>XHaLe project<\/strong>, a team of researchers set out to help answer this question and achieved new insights into the effects of SARS-CoV-2 on the lungs. Their findings were published in <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2015432\">\u2018The New England Journal of Medicine\u2019<\/a>. The researchers examined tissue samples from patients who died from COVID-19 and compared them with those obtained \u201cfrom patients who died from acute respiratory distress syndrome (ARDS) secondary to influenza A(H1N1) infection,\u201d as noted in the journal article.<\/div>\n<div class=\"row c-article__below-teaser\">\n<div>\n<div class=\"ng-star-inserted\">\n<p class=\"c-article__text\">Summarising the findings of the study in a <a href=\"http:\/\/erc.europa.eu\/news-events\/magazine\/frontier-research-service-coronavirus-epidemic-response#bootstrap-panel-5-body\">news item<\/a> on the European Research Council website, Prof. Dr Danny Jonigk from XHaLe project host Hannover Medical School states:<\/p>\n<blockquote>\n<p class=\"c-article__text\">\u201cFirstly, we were able to confirm an already known damage to the lungs, which occurs when the walls of the alveoli become inflamed. This phenomenon makes it difficult for oxygen to enter the blood. Secondly, we found a massive number of blood clots in all sections of the blood vessels, but particularly in the finest pulmonary vessels. This is what further increases the breathlessness of coronavirus patients and is similar, but less severe, in influenza patients.\u201d<\/p>\n<\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div>\n<h3 class=\"c-article__title\">A distinct pulmonary pathobiology<\/h3>\n<p class=\"c-article__text\">Another observation of the team involves a feature of the coronavirus \u201cthat is usually encountered only by physicians analysing tumours or autoimmune diseases,\u201d according to Prof. Dr Jonigk, who adds that COVID-19 \u201capparently triggers a special form of vascularisation in the lungs, an abnormal formation of blood vessels.\u201d This is what \u201cfundamentally distinguishes Covid-19 from the severe lung infections caused by influenza viruses,\u201d he states.<\/p>\n<p class=\"c-article__text\">In the journal article, the researchers also emphasise that their sample was small \u2013 it covered 7 lungs from patients who died from COVID-19, 7 lungs from patients who died from ARDS secondary to influenza A(H1N1) and \u201c10 age-matched, uninfected control lungs.\u201d They conclude: \u201cIn our small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.\u201d They note that further research is required to fully understand the mechanisms of the vascular changes in COVID-19 victims. \u201cAdditional work is needed to relate our findings to the clinical course in these patients.\u201d<\/p>\n<h3>More information<\/h3>\n<p><a href=\"https:\/\/cordis.europa.eu\/article\/id\/421597-how-covid-19-damages-the-lungs\/es\">Full news<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>A team of EU-backed researchers has compared the lungs of coronavirus victims and patients dead from influenza-associated respiratory failure. Why does the coronavirus impact the lungs so brutally? Partially supported by the EU-funded XHaLe project, a team of researchers set out to help answer this question and achieved new insights into the effects of SARS-CoV-2 [&hellip;]<\/p>\n","protected":false},"author":101012,"featured_media":49784,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[4093,346,4092],"tags":[1352,2366,2135],"class_list":{"0":"post-49786","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-diseases","8":"category-eu-news","9":"category-health","10":"tag-covid-19","11":"tag-covid-19-2-en","12":"tag-lungs","13":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How COVID-19 damages the lungs | CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cde.ual.es\/en\/how-covid-19-damages-the-lungs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How COVID-19 damages the lungs | CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda\" \/>\n<meta property=\"og:description\" content=\"A team of EU-backed researchers has compared the lungs of coronavirus victims and patients dead from influenza-associated respiratory failure. 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