{"id":32059,"date":"2019-12-26T03:00:00","date_gmt":"2019-12-26T02:00:00","guid":{"rendered":"https:\/\/www.cde.ual.es\/?p=32059"},"modified":"2019-12-23T12:48:59","modified_gmt":"2019-12-23T11:48:59","slug":"the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/www.cde.ual.es\/en\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\/","title":{"rendered":"The breakdown of clumped tau proteins to cure Alzheimer\u2019s disease"},"content":{"rendered":"<div class=\"teaser-text\">\n<p>Proteins are the building blocks of the cell machinery but faulty structure can cause havoc as in Alzheimer\u2019s disease. EU research is delving into how \u2018clumps\u2019 of an abnormal version of the tau protein present in this neurodegenerative disorder and find ways to disassemble them.<a href=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280.jpg\"><img decoding=\"async\" class=\"size-medium wp-image-32057 aligncenter\" src=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280-300x169.jpg\" alt=\"\" width=\"300\" height=\"169\" srcset=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280-300x169.jpg 300w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280-768x432.jpg 768w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280-1024x576.jpg 1024w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280.jpg 1280w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<div class=\"ng-star-inserted\">\n<p class=\"general-text ng-star-inserted\">According to the World Health Organization, more than 47 million people worldwide are affected by dementia, with Alzheimer\u2019s disease being the most common and widespread among them (60-70 %). One feature that Alzheimer\u2019s patients have in common is the presence of rod-like structures known as amyloid fibrils. Composed of a protein tau in its aggregated form, these have also been implicated in a number of other neurodegenerative diseases (tauopathies). These include frontotemporal dementia, progressive supranuclear palsy and primary age-related tauopathy. In healthy neurons, the tau protein stabilises microtubules that help guide nutrients from the cell neuron body to the axon and dendrites. In Alzheimer\u2019s disease, however, abnormal chemical changes cause tau to detach from microtubules and stick to other tau molecules, forming threads that eventually join to form tangles inside neurons. These tangles block the neuron\u2019s transport system, which harms the synaptic communication between neurons. Despite major research efforts, the mechanism of tau aggregation and its pathogenic consequences are not yet understood. Therapeutics to cure these tauopathies, including Alzheimer\u2019s disease, are urgently needed.<\/p>\n<\/div>\n<div class=\"ng-star-inserted\">\n<h3 class=\"auto-height articles-section-title ng-star-inserted\">Untangling tau<\/h3>\n<p class=\"general-text ng-star-inserted\">Saurabh Gautam, post-doctoral Marie Sk\u0142odowska-Curie research fellow with the REVERSING TAUOPATHY project outlined the objective of the initiative: \u201cOur goal at the Max Planck Institute of Biochemistry was to find out the conditions for dissolution of such protein aggregates in the human cellular model of tau \u2018clumping\u2019 or aggregation.\u201d The mechanism and cellular machinery involved in the dissolution of these tau aggregates could lead to the development of lead compounds for new drugs. Preliminary work identified two main conditions when tau aggregates were disassembled. Starvation of the cell model using a medium devoid of amino acids \u2013 Earle&#8217;s Balanced Salt Solution \u2013 caused aggregate breakdown. Switching off the expression of the tau protein also caused disaggregation of the rogue protein. The researchers then used state-of-art techniques such as stable isotope labelling with amino acids in cell culture \u2013 SILAC based mass spectrometry, to identify the components of the cellular machinery involved in the dissolution of tau aggregates. \u201cAfter screening various conditions with this popular method for quantitative proteomics, we were able to show that intracellular tau aggregates can be disassembled in the cells, a huge breakthrough,\u201d Gautam declares.<\/p>\n<div>\n<h3 class=\"general-text\">More information<\/h3>\n<\/div>\n<div>\n<h3><a style=\"font-size: 16px;\" href=\"https:\/\/cordis.europa.eu\/article\/id\/411682-the-breakdown-of-clumped-tau-proteins-to-cure-alzheimer-s-disease\">Full News<\/a><\/h3>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Proteins are the building blocks of the cell machinery but faulty structure can cause havoc as in Alzheimer\u2019s disease. EU research is delving into how \u2018clumps\u2019 of an abnormal version of the tau protein present in this neurodegenerative disorder and find ways to disassemble them. According to the World Health Organization, more than 47 million [&hellip;]<\/p>\n","protected":false},"author":101011,"featured_media":32057,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[346],"tags":[951,950,949],"class_list":{"0":"post-32059","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-eu-news","8":"tag-alzheimer-en","9":"tag-cure","10":"tag-protein","11":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The breakdown of clumped tau proteins to cure Alzheimer\u2019s disease | CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cde.ual.es\/en\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The breakdown of clumped tau proteins to cure Alzheimer\u2019s disease | CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda\" \/>\n<meta property=\"og:description\" content=\"Proteins are the building blocks of the cell machinery but faulty structure can cause havoc as in Alzheimer\u2019s disease. 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According to the World Health Organization, more than 47 million [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cde.ual.es\/en\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/cdeuniversidadalmeria\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-12-26T02:00:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/12\/dna-163710_1280.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"BECA 2 CDE\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@cdeualmeria\" \/>\n<meta name=\"twitter:site\" content=\"@cdeualmeria\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"BECA 2 CDE\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/\"},\"author\":{\"name\":\"BECA 2 CDE\",\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/#\\\/schema\\\/person\\\/ee46ebc19edfa19598c02cff83335acc\"},\"headline\":\"The breakdown of clumped tau proteins to cure Alzheimer\u2019s disease\",\"datePublished\":\"2019-12-26T02:00:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/\"},\"wordCount\":426,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.cde.ual.es\\\/wp-content\\\/uploads\\\/2019\\\/12\\\/dna-163710_1280.jpg\",\"keywords\":[\"Alzheimer\",\"cure\",\"Protein\"],\"articleSection\":[\"EU News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/\",\"url\":\"https:\\\/\\\/www.cde.ual.es\\\/en\\\/the-breakdown-of-clumped-tau-proteins-to-cure-alzheimers-disease\\\/\",\"name\":\"The breakdown of clumped tau proteins to cure Alzheimer\u2019s disease | CDE Almer\u00eda - 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