{"id":27452,"date":"2019-10-18T03:00:08","date_gmt":"2019-10-18T01:00:08","guid":{"rendered":"https:\/\/www.cde.ual.es\/?p=27452"},"modified":"2019-10-18T08:44:07","modified_gmt":"2019-10-18T06:44:07","slug":"a-minimally-invasive-prognostic-device-for-breast-cancer","status":"publish","type":"post","link":"https:\/\/www.cde.ual.es\/en\/a-minimally-invasive-prognostic-device-for-breast-cancer\/","title":{"rendered":"A minimally-invasive prognostic device for breast cancer"},"content":{"rendered":"<p><em><strong>Dealing with suspected breast cancer is a traumatic experience, one that\u2019s only worsened by how invasive current diagnostic and prognostic tools are.\u00a0<\/strong><\/em><\/p>\n<p><a href=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/10\/awareness-cancer-design-579474.jpg\"><img decoding=\"async\" class=\"size-medium wp-image-27135 aligncenter\" src=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/10\/awareness-cancer-design-579474-300x199.jpg\" alt=\"\" width=\"300\" height=\"199\" srcset=\"https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/10\/awareness-cancer-design-579474-300x199.jpg 300w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/10\/awareness-cancer-design-579474-768x511.jpg 768w, https:\/\/www.cde.ual.es\/wp-content\/uploads\/2019\/10\/awareness-cancer-design-579474-1024x681.jpg 1024w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Surgical sentinel lymph node biopsy (SLNB) has become the undisputed method for breast cancer prognosis since it was first reported in 1992. Steady improvements in survival rates have been observed over the past few decades, and also thanks to the over 90 % accuracy of SLNB in defining cancer stages and predicting treatment outcomes.<\/p>\n<div class=\"ng-star-inserted\">\n<p>The technique, however, has also its downsides. As Dr Francesc Mitjans, Director of Health and Biomedicine at Leitat, claims: <em>\u201cThere is a real, unmet clinical need for a more reliable and less invasive prognostic alternative, both for the patients themselves and for health practitioners.\u201d <\/em><\/p>\n<p>SLNB is indeed highly invasive. It can also feel over the top with its 70 % negative results and the wasted resources that come with it. With each negative SLNB, the health system loses up to EUR 15 000.<\/p>\n<p>In fact, this is just the tip of the iceberg. Some patients have exhibited allergic reactions to the injected dye or have seen damaged lymphatic vessels swell and eventually cause lymphatic oedema. Moreover, results delivery can take up to 2 weeks and, in 5 to 10 % of cases, turn out to be false negatives.<\/p>\n<p><em>\u201cHypoSens set out to provide patients, surgeons and oncologists with an innovative prognostic system that addresses these shortcomings,\u201d<\/em> Dr Mitjans says.<\/p>\n<\/div>\n<div class=\"ng-star-inserted\"><\/div>\n<div class=\"ng-star-inserted\">\n<h3 class=\"general-text ng-star-inserted\">Other prognostic alternatives<\/h3>\n<div class=\"ng-star-inserted\">\n<p class=\"general-text ng-star-inserted\">The HypoSens (Nano-confined photonic system for detection of breast cancer spread to the lymph nodes) project\u2019s imaging system combines the use of specific anti-HER2 antibodies to target cancer cells with dual parameter (local T\u00ba C and O2) nanosensors.<\/p>\n<p class=\"general-text ng-star-inserted\">It also encompasses an external non-invasive near-infrared (NIR) probe device which can register signals through the skin using the wavefront shaping concept. The latter processes data collected by injected nanosensors that target the tumour, and overcomes the current limits of imaging through highly scattering tissue.<\/p>\n<p class=\"general-text ng-star-inserted\"><em>\u201cOur system will offer faster, better and less painful prognostic alternatives to breast cancer patients, as no surgery is required,\u201d<\/em> Dr Mitjans explains. <em>\u201cThe ability to provide final prognostic results immediately will also save patients the anxiety caused by current options.\u201d <\/em><\/p>\n<p class=\"general-text ng-star-inserted\">The project consortium has already obtained the ethical clearances required to conduct studies on animals and clinical samples. They have drafted a business plan for the future commercialisation of the technology, which foresees an upgrade from lab scale to commercial production.<\/p>\n<p class=\"general-text ng-star-inserted\"><em>\u201cOur business plan identifies which components need to be modified for successful commercialisation and maps a way forward for needful modifications. We have already set up various strategies to catch the attention of the public, investors, the medical research sector, academia, SMEs and cancer associations,\u201d<\/em> Dr Mitjans points out.<\/p>\n<\/div>\n<div class=\"ng-star-inserted\">\n<h3 class=\"auto-height articles-section-title ng-star-inserted\">Future steps<\/h3>\n<p class=\"general-text ng-star-inserted\">The team is working hard to bring the device to patients in the near future. <em>\u201cWe are planning for a 6-month-long trial targeting up to 400 patients with HER2-positive breast cancer across Europe, to compare pathology data with data gathered by HypoSens. We also have to seek formal CE certification and FDA approval. To ensure widespread production, we plan to license the technology to industry-leading medical device manufacturers in Europe,\u201d<\/em> Dr Mitjans says.<\/p>\n<p class=\"general-text ng-star-inserted\">Although the HypoSens system was initially meant to focus on breast cancer, the team is now considering its use for the diagnosis and prognostic of other metastatic cancers. These include vulval, colorectal and gastric cancers, as well as pelvic and renal tumours via the use of other tumour-targeting moieties.<\/p>\n<\/div>\n<\/div>\n<h3>More information<\/h3>\n<p><a href=\"https:\/\/cordis.europa.eu\/project\/rcn\/206198\/brief\/en\">Full news<\/a><\/p>\n<p><a href=\"http:\/\/hyposens.eu\/\">HypoSens<\/a><\/p>\n<p>More information in the\u00a0<a href=\"https:\/\/www.cde.ual.es\/en\/research\/\">R+I Section<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dealing with suspected breast cancer is a traumatic experience, one that\u2019s only worsened by how invasive current diagnostic and prognostic tools are.\u00a0 Surgical sentinel lymph node biopsy (SLNB) has become the undisputed method for breast cancer prognosis since it was first reported in 1992. Steady improvements in survival rates have been observed over the past [&hellip;]<\/p>\n","protected":false},"author":101012,"featured_media":27136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_genesis_hide_title":false,"_genesis_hide_breadcrumbs":false,"_genesis_hide_singular_image":false,"_genesis_hide_footer_widgets":false,"_genesis_custom_body_class":"","_genesis_custom_post_class":"","_genesis_layout":"","footnotes":""},"categories":[346],"tags":[437,354,404,433],"class_list":{"0":"post-27452","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-eu-news","8":"tag-health","9":"tag-innovacion-en","10":"tag-innovation","11":"tag-research","12":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A minimally-invasive prognostic device for breast cancer | CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cde.ual.es\/en\/a-minimally-invasive-prognostic-device-for-breast-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A minimally-invasive prognostic device for breast cancer | CDE Almer\u00eda - Centro de Documentaci\u00f3n Europea - Universidad de Almer\u00eda\" \/>\n<meta property=\"og:description\" content=\"Dealing with suspected breast cancer is a traumatic experience, one that\u2019s only worsened by how invasive current diagnostic and prognostic tools are.\u00a0 Surgical sentinel lymph node biopsy (SLNB) has become the undisputed method for breast cancer prognosis since it was first reported in 1992. 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